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Piceatannol
Chemical compound From Wikipedia, the free encyclopedia
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Piceatannol is the organic compound with the formula ((HO)2C6H3)2CH)2. It can be classified as a stilbenoid, a phenol, and a polyphenol. It is a white solid, although samples often are yellow owing to impurities. The chemical structure of piceatannol was established as being an analog of resveratrol.[1]
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Natural occurrences
Piceatannol and its glucoside, astringin, are found in mycorrhizal and non-mycorrhizal roots of Norway spruces (Picea abies).[2] It can also be found in the seeds of the palm Aiphanes horrida[3] and in Gnetum cleistostachyum.[4] Passion fruit seeds are rich in piceatannol and scirpusin B (dimer of piceatannol).[5]
In food
Piceatannol is a metabolite of resveratrol found in red wine, grapes, passion fruit, white tea, and Japanese knotweed.[6] Astringin, a piceatannol glucoside, is also found in red wine. The formation of piceatannol from resveratrol is catalyzed by cytochrome P450.[7]
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Biochemistry
Piceattanol acts as an inhibitor of the tyrosine kinase Syk and some related tyrosine kinases.[8] In the early 2000s, this prompted research interest in piceatannol and its effect on immune or inflammatory diseases.[9]
Injected in rats, piceatannol shows a rapid glucuronidation and a poor bioavailability, according to a 2006 study.[10]
Piceatannol affect gene expressions, gene functions and insulin action, resulting in the delay or complete inhibition of adipogenesis.[11][12]
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See also
References
Further reading
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