Platelet-activating factor receptor

The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor.^[5][6] It is encoded in the human by the PTAFR gene.

PTAFR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B0X
Identifiers
Aliases	PTAFR, PAFR, platelet activating factor receptor
External IDs	OMIM: 173393; MGI: 106066; HomoloGene: 20260; GeneCards: PTAFR; OMA:PTAFR - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 28,147,166 bp[1] End 28,193,936 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.3|4 65.56 cM Start 132,291,378 bp[2] End 132,309,994 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte bone marrow vena cava nasal epithelium pericardium cecum body of tongue bone marrow cells Top expressed in granulocyte bone marrow white adipose tissue jejunum esophagus ileum spleen zone of skin urinary bladder muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity G protein-coupled purinergic nucleotide receptor activity lipopolysaccharide binding signal transducer activity mitogen-activated protein kinase binding platelet activating factor receptor activity phospholipid binding lipopolysaccharide immune receptor activity protein binding Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane secretory granule membrane tertiary granule membrane Biological process G protein-coupled receptor signaling pathway positive regulation of leukocyte tethering or rolling inositol trisphosphate biosynthetic process positive regulation of voltage-gated chloride channel activity positive regulation of phospholipase C activity negative regulation of blood pressure interferon-gamma-mediated signaling pathway positive regulation of inositol phosphate biosynthetic process regulation of transcription by RNA polymerase II positive regulation of transcytosis cytokine production response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine response to symbiotic bacterium transcytosis positive regulation of translation cellular response to gravity response to dexamethasone positive regulation of cellular extravasation positive regulation of maternal process involved in parturition chemotaxis cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine positive regulation of sensory perception of pain response to lipopolysaccharide cellular response to fatty acid response to organophosphorus birth positive regulation of vasoconstriction immune response positive regulation of gastro-intestinal system smooth muscle contraction positive regulation of tumor necrosis factor production inflammatory response positive regulation of smooth muscle contraction positive regulation of neutrophil degranulation positive regulation of leukocyte cell-cell adhesion phosphatidylinositol-mediated signaling lipopolysaccharide-mediated signaling pathway cellular response to cAMP signal transduction positive regulation of smooth muscle cell proliferation G protein-coupled purinergic nucleotide receptor signaling pathway neutrophil degranulation cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5724 19204 Ensembl ENSG00000169403 ENSMUSG00000056529 UniProt P25105 Q62035 RefSeq (mRNA) NM_001164723 NM_000952 NM_001164721 NM_001164722 NM_001081211 RefSeq (protein) NP_000943 NP_001158193 NP_001158194 NP_001158195 NP_001074680 Location (UCSC) Chr 1: 28.15 – 28.19 Mb Chr 4: 132.29 – 132.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM]^[7] Its pathogenetic role in chronic kidney failure has also been reported recently.^[8]

Ligands

Agonists

• Platelet activating factor

Antagonists

• Apafant (WEB-2086)
• Israpafant (Y-24180)
• Lexipafant
• Rupatadine