Poly(a) binding protein interacting protein 2b

Poly(A) binding protein interacting protein 2B is a protein that in humans is encoded by the PAIP2B gene. ^[5]

PAIP2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JGN, 3KUS, 3KUT
Identifiers
Aliases	PAIP2B, poly(A) binding protein interacting protein 2B
External IDs	OMIM: 611018; MGI: 2386865; HomoloGene: 25798; GeneCards: PAIP2B; OMA:PAIP2B - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 71,182,738 bp[1] End 71,227,103 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 83,782,383 bp[2] End 83,808,723 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum internal globus pallidus inferior ganglion of vagus nerve C1 segment Skeletal muscle tissue of rectus abdominis subthalamic nucleus dorsal motor nucleus of vagus nerve middle frontal gyrus substantia nigra optic nerve Top expressed in primary oocyte lacrimal gland parotid gland zygote secondary oocyte sternocleidomastoid muscle seminal vesicula vestibular membrane of cochlear duct extensor digitorum longus muscle temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding translation repressor activity, mRNA regulatory element binding Cellular component cytoplasm Biological process negative regulation of translational initiation regulation of translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 400961 232164 Ensembl ENSG00000124374 ENSMUSG00000045896 UniProt Q9ULR5 Q91W45 RefSeq (mRNA) NM_020459 NM_146169 RefSeq (protein) NP_065192 NP_666281 Location (UCSC) Chr 2: 71.18 – 71.23 Mb Chr 6: 83.78 – 83.81 Mb PubMed search [3] [4]
Wikidata
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Function

Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008].