Polypyrimidine tract-binding protein

Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization.^[1] Two 2020 studies have shown that depleting PTB mRNA in astrocytes can convert these astrocytes to functional neurons.^[2][3] These studies also show that such a treatment can be applied to the substantia nigra of mice models of Parkinson's disease in order to convert astrocytes to dopaminergic neurons and as a consequence restore motor function in these mice.

polypyrimidine tract binding protein 1
Identifiers
Symbol	PTBP1
Alt. symbols	PTB
NCBI gene	5725
HGNC	9583
OMIM	600693
RefSeq	NM_002819
UniProt	P26599
Other data
Locus	Chr. 19 p13.3
Search for Structures Swiss-model Domains InterPro

polypyrimidine tract binding protein 2
Identifiers
Symbol	PTBP2
NCBI gene	58155
HGNC	17662
OMIM	608449
RefSeq	NM_021190
UniProt	Q9UKA9
Other data
Locus	Chr. 1 p21.3-22.1
Search for Structures Swiss-model Domains InterPro

See also

• Polypyrimidine tract