PTBP2

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.^[5][6]

PTBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQ1, 2MJU, 4CQ1
Identifiers
Aliases	PTBP2, PTBLP, brPTB, nPTB, polypyrimidine tract binding protein 2
External IDs	OMIM: 608449; MGI: 1860489; HomoloGene: 23162; GeneCards: PTBP2; OMA:PTBP2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p21.3 Start 96,721,665 bp[1] End 96,823,738 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 119,512,391 bp[2] End 119,578,115 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence corpus callosum ventricular zone Achilles tendon pars compacta gastric mucosa secondary oocyte pars reticulata testicle muscle layer of sigmoid colon Top expressed in spermatocyte genital tubercle medial ganglionic eminence tail of embryo pineal gland superior cervical ganglion ventricular zone ventral tegmental area ventromedial nucleus maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function mRNA binding pre-mRNA binding nucleic acid binding RNA binding Cellular component growth cone spliceosomal complex soma nucleus Biological process mRNA splice site selection cerebellum development mRNA processing RNA splicing spinal cord development regulation of neural precursor cell proliferation negative regulation of RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58155 56195 Ensembl ENSG00000117569 ENSMUSG00000028134 UniProt Q9UKA9 Q91Z31 RefSeq (mRNA) NM_001300985 NM_001300986 NM_001300987 NM_001300988 NM_001300989 NM_001300990 NM_021190 NM_019550 NM_001310711 RefSeq (protein) NP_001287914 NP_001287915 NP_001287916 NP_001287917 NP_001287918 NP_001287919 NP_067013 NP_001297640 NP_062423 Location (UCSC) Chr 1: 96.72 – 96.82 Mb Chr 3: 119.51 – 119.58 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.^[6]