Prolactin-releasing peptide receptor

The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR gene.

PRLHR
Identifiers
Aliases	PRLHR, GPR10, GR3, PrRPR, prolactin releasing hormone receptor
External IDs	OMIM: 600895; MGI: 2135956; HomoloGene: 3134; GeneCards: PRLHR; OMA:PRLHR - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.11 Start 118,589,997 bp[1] End 118,595,648 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D3 Start 60,455,170 bp[2] End 60,456,742 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary islet of Langerhans Hypothalamus substantia nigra prefrontal cortex body of uterus vagina myometrium smooth muscle tissue Top expressed in Hypothalamus Cerebellum cerebellar cortex striatum of neuraxis Mesencephalon More reference expression data BioGPS n/a
Gene ontology Molecular function neuropeptide Y receptor activity G protein-coupled receptor activity protein binding signal transducer activity neuropeptide receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane cilium Biological process female pregnancy G protein-coupled receptor signaling pathway hormone metabolic process feeding behavior signal transduction neuropeptide signaling pathway chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2834 226278 Ensembl ENSG00000119973 ENSMUSG00000045052 UniProt P49683 Q6VMN6 RefSeq (mRNA) NM_004248 NM_201615 RefSeq (protein) NP_004239 NP_963909 Location (UCSC) Chr 10: 118.59 – 118.6 Mb Chr 19: 60.46 – 60.46 Mb PubMed search [3] [4]
Wikidata
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PrRPR is a G-protein coupled receptor^[5] that binds the prolactin-releasing peptide (PRLH).^[6]

Function

PrRPR is a 7-transmembrane domain receptor for prolactin-releasing peptide that is highly expressed in the anterior pituitary.^[7]