Propentofylline

Propentofylline (HWA 285) is a xanthine derivative drug with purported neuroprotective effects.

Propentofylline

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N06BC02 (WHO) QC04AD90 (WHO)
Identifiers
IUPAC name 3-methyl-1-(5-oxohexyl)-7-propyl-3,7-dihydro-1H-purine-2,6-dione
CAS Number	55242-55-2 Y
PubChem CID	4938
ChemSpider	4769
UNII	5RTA398U4H
CompTox Dashboard (EPA)	DTXSID4045189
ECHA InfoCard	100.133.568
Chemical and physical data
Formula	C15H22N4O3
Molar mass	306.366 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCn1cnc2c1c(=O)n(c(=O)n2C)CCCCC(=O)C
InChI InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3 Key:RBQOQRRFDPXAGN-UHFFFAOYSA-N
(verify)

Pharmacology

It is a phosphodiesterase inhibitor,^[1] and also acts as an adenosine reuptake inhibitor.^[1][2][3]

Uses

Propentofylline was studied as a possible treatment for Alzheimer's disease and multi-infarct dementia,^[1][4] and has been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties.^[5][6]

Propentofylline is in use as a veterinary medicine in older dogs.^[7]

See also

• Pentoxifylline

External links

• Summary of research, including possible multipartite mechanisms