Propisergide

Propisergide
Clinical data
Other names	Ergalgin; N-Methylergobasine; N-Methylergonovine; N-Methylergometrine; 1-Methylergonovine
Drug class	Serotonin receptor modulator; Antimigraine agent
Identifiers
	IUPAC name (6aR,9R)-N-[(2S)-1-hydroxypropan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide;
CAS Number	5793-04-4;
PubChem CID	20055549;
ChemSpider	16737112;
UNII	1Q1AWW2JET;
ChEMBL	ChEMBL3989790;
CompTox Dashboard (EPA)	DTXSID701018134 ;
Chemical and physical data
Formula	C20H25N3O2
Molar mass	339.439 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H](CO)NC(=O)[C@H]1CN([C@@H]2CC3=CN(C4=CC=CC(=C34)C2=C1)C)C;
	InChI InChI=1S/C20H25N3O2/c1-12(11-24)21-20(25)14-7-16-15-5-4-6-17-19(15)13(9-22(17)2)8-18(16)23(3)10-14/h4-7,9,12,14,18,24H,8,10-11H2,1-3H3,(H,21,25)/t12-,14+,18+/m0/s1; Key:XUKAVPATXGYVKJ-WPKBUWHJSA-N;

Propisergide (INNTooltip International Nonproprietary Name), also known as ergalgin or as N-methylergometrine or 1-methylergometrine, is a serotonin receptor modulator and antimigraine agent of the ergoline and lysergamide families which was never marketed.^[1]^[2]^[3]^[4] It is the 1-methyl derivative of ergometrine (ergonovine) and is a close analogue of methylergonovine and methysergide.^[5] The drug was first described in the literature by 1962^[6] and then further around 1980 and after.^[4]^[7]^[8]

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References