Protein BEX1

Protein BEX1 also known as brain-expressed X-linked protein 1 is a protein that in humans is encoded by the BEX1 gene.^[5] BEX1 is apart of the BEX gene family well conserved in mammals. It is expressed in a wide range of tissues.^[6] BEX proteins have connections to cancer and their direct functions are not fully understood. BEX1 is suggested to act as a tumor suppresant in certain situations. ^[6]

BEX1
Identifiers
Aliases	BEX1, BEX2, HBEX2, HGR74-h, brain expressed X-linked 1
External IDs	OMIM: 300690; MGI: 1338017; HomoloGene: 135613; GeneCards: BEX1; OMA:BEX1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1|Xq22 Start 103,062,651 bp[1] End 103,064,171 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F1|X 57.37 cM Start 134,967,313 bp[2] End 134,968,985 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus orbitofrontal cortex primary visual cortex dorsolateral prefrontal cortex superior frontal gyrus Brodmann area 9 prefrontal cortex pituitary gland Top expressed in arcuate nucleus ventromedial nucleus paraventricular nucleus of hypothalamus temporal lobe amygdala dorsomedial hypothalamic nucleus lateral septal nucleus anterior amygdaloid area lateral hypothalamus median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus transcription regulator complex Biological process multicellular organism development cell differentiation positive regulation of DNA-binding transcription factor activity nervous system development positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55859 12069 Ensembl ENSG00000133169 ENSMUSG00000042750 UniProt Q9HBH7 Q9WTZ8 RefSeq (mRNA) NM_018476 NM_009749 RefSeq (protein) NP_060946 NP_033879 Location (UCSC) Chr X: 103.06 – 103.06 Mb Chr X: 134.97 – 134.97 Mb PubMed search [3] [4]
Wikidata
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