Protein geranylgeranyltransferase type I subunit beta

Protein geranylgeranyltransferase type I subunit beta is a protein that in humans is encoded by the PGGT1B gene.^[5]

PGGT1B
Identifiers
Aliases	PGGT1B, BGGI, GGTI, protein geranylgeranyltransferase type I subunit beta
External IDs	OMIM: 602031; MGI: 1917514; HomoloGene: 3685; GeneCards: PGGT1B; OMA:PGGT1B - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.3 Start 115,204,012 bp[1] End 115,262,877 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 C Start 46,368,418 bp[2] End 46,414,060 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte monocyte palpebral conjunctiva mucosa of sigmoid colon Achilles tendon rectum islet of Langerhans amniotic fluid epithelium of colon Top expressed in hand otolith organ utricle pineal gland renal corpuscle prostate lobe of prostate otic vesicle foot lacrimal gland More reference expression data BioGPS n/a
Gene ontology Molecular function prenyltransferase activity zinc ion binding protein geranylgeranyltransferase activity metal ion binding catalytic activity isoprenoid binding peptide binding transferase activity CAAX-protein geranylgeranyltransferase activity Cellular component CAAX-protein geranylgeranyltransferase complex Biological process negative regulation of nitric-oxide synthase biosynthetic process positive regulation of cell cycle positive regulation of cell population proliferation response to cytokine protein geranylgeranylation protein prenylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5229 225467 Ensembl ENSG00000164219 ENSMUSG00000024477 UniProt P53609 Q8BUY9 RefSeq (mRNA) NM_005023 NM_172627 RefSeq (protein) NP_005014 NP_766215 Location (UCSC) Chr 5: 115.2 – 115.26 Mb Chr 18: 46.37 – 46.41 Mb PubMed search [3] [4]
Wikidata
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Function

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010].