Pycnoporopepsin

Pycnoporopepsin (EC 3.4.23.30, proteinase Ia, Pycnoporus coccineus aspartic proteinase, Trametes acid proteinase) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction

Similar to pepsin A, but narrower, cleaving only three bonds in the B chain of insulin: Ala¹⁴-Leu, Tyr¹⁶-Leu, and Phe²⁴-Phe

Pycnoporopepsin
Identifiers
EC no.	3.4.23.30
CAS no.	77967-78-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme is isolated from the basidiomycete Pycnoporus sanguineus.