Pyroglutamylated RFamide peptide receptor

Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene.^[5][6]

QRFPR
Identifiers
Aliases	QRFPR, AQ27, GPR103, SP9155, pyroglutamylated RFamide peptide receptor
External IDs	OMIM: 606925; MGI: 2677633; HomoloGene: 18865; GeneCards: QRFPR; OMA:QRFPR - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q27 Start 121,328,642 bp[1] End 121,381,059 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 36,233,573 bp[2] End 36,276,462 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad renal cortex left ventricle prefrontal cortex primary visual cortex Hypothalamus right auricle of heart apex of heart superior frontal gyrus bone marrow cells Top expressed in ventromedial nucleus piriform cortex embryo tail of embryo neural layer of retina lumbar subsegment of spinal cord temporal lobe ventricular zone olfactory bulb paraventricular nucleus of hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function neuropeptide Y receptor activity peptide binding G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process cellular response to hormone stimulus neuropeptide signaling pathway signal transduction response to peptide G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84109 229214 Ensembl ENSG00000186867 ENSMUSG00000058400 UniProt Q96P65 P83861 RefSeq (mRNA) NM_198179 NM_198192 RefSeq (protein) NP_937822 NP_937835 Location (UCSC) Chr 4: 121.33 – 121.38 Mb Chr 3: 36.23 – 36.28 Mb PubMed search [3] [4]
Wikidata
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Function

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.^[5]

A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.^[7] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.^[8]