Pyrrolidinylethylindole

Pyrrolidinylethylindoles, or 3-(2-pyrrolidinylethyl)indoles, also known as pyr-tryptamines or N,N-tetramethylenetryptamines, are a group of cyclized tryptamines in which the amine has been replaced with or cyclized into a pyrrolidine ring. They can also be thought of as derivatives of the psychedelic tryptamine N,N-diethyltryptamine (DET) in which the ethyl groups attached to the amine have been connected together to form a ring. Examples of pyrrolidinylethylindoles include pyr-T, 4-HO-pyr-T, 5-MeO-pyr-T, and 4-F-5-MeO-pyr-T.

Pyrrolidinylethylindoles are known to act as serotonin receptor agonists, primarily of the serotonin 5-HT_1A receptor and to variably lesser extents of the serotonin 5-HT_2A receptor. In addition, they are known to be psychoactive drugs and some have psychedelic-like effects, although they are very different in their subjective effects compared to other psychedelic tryptamines.^{[1][2][3][4][5][6][7][8][9][10]}

Chemical structures of selected pyrrolidinylethylindoles

• 
  Pyr-T
• 
  4-HO-pyr-T
• 
  5-MeO-pyr-T
• 
  4-F-5-MeO-pyr-T

See also

• Cyclized tryptamine
• Pyrrolidinylmethylindole
• Pip-Tryptamine