Top Qs
Timeline
Chat
Perspective
4-F-5-MeO-pyr-T
Pharmaceutical compound From Wikipedia, the free encyclopedia
Remove ads
4-F-5-MeO-pyr-T, also known as 4-fluoro-5-methoxy-N,N-pyrrolidinyltryptamine, is a serotonin 5-HT1A receptor agonist of the tryptamine and pyrrolidinylethylindole families.[1][2][3][4] It is a derivative of pyr-T and 5-MeO-DMT.[1][2][3]
Remove ads
Pharmacology
Summarize
Perspective
4-F-5-MeO-pyr-T acts as a highly potent and selective serotonin 5-HT1A receptor full agonist.[1][2][3] It shows about 813-fold selectivity in activating this receptor over the related serotonin 5-HT2A receptor.[4] The drug shows little activity at other serotonin receptors besides the serotonin 5-HT1A receptor and little activity at the serotonin transporter (SERT) or other monoamine transporters (MATs).[4]
4-F-5-MeO-pyr-T does not produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, and this is the case regardless of whether it is administered alone or in combination with the serotonin 5-HT1A receptor antagonist WAY-100635.[4] Likewise, 4-F-5-MeO-pyr-T does not substitute for the psychedelics DOI and LSD in animal drug discrimination tests.[3] However, it fully substitutes for the serotonin 5-HT1A receptor full agonist LY-293284 in such tests.[3] 4-F-5-MeO-pyr-T produces serotonin 5-HT1A receptor-dependent antidepressant-like effects in rodents.[4][5] It also dose-dependently produces hypolocomotion in rodents.[4] At higher doses, 4-F-5-MeO-pyr-T induces a pronounced serotonin syndrome and behavioral disruption in rodents, including flat body posture and forepaw treading.[3]
4-F-5-MeO-pyr-T is a potential alternative to 8-OH-DPAT as a serotonin 5-HT1A receptor agonist for use in scientific research.[3]
Remove ads
History
4-F-5-MeO-pyr-T was first synthesized and described by David E. Nichols and colleagues in 2001.[1][2][3]
See also
References
External links
Wikiwand - on
Seamless Wikipedia browsing. On steroids.
Remove ads