QPCT

Glutaminyl-peptide cyclotransferase is an enzyme that in humans is encoded by the QPCT gene.^[5][6]

QPCT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZEE, 2ZEF, 2AFU, 2AFM, 2AFX, 4YU9, 2ZEL, 2ZEG, 2ZEM, 4YWY, 2AFZ, 3PBB, 2ZEH, 2AFS, 3SI0, 2ZEP, 3PBE, 2ZEO, 2ZED, 2AFO, 2ZEN, 2AFW
Identifiers
Aliases	QPCT, GCT, QC, sQC, glutaminyl-peptide cyclotransferase
External IDs	OMIM: 607065; MGI: 1917786; HomoloGene: 8238; GeneCards: QPCT; OMA:QPCT - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.2 Start 37,342,827 bp[1] End 37,373,322 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E3 Start 79,359,335 bp[2] End 79,397,807 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex beta cell left adrenal gland left adrenal cortex blood bone marrow cell monocyte skin of arm trabecular bone corpus epididymis Top expressed in spermatocyte lens lumbar subsegment of spinal cord iris neural layer of retina arcuate nucleus paraventricular nucleus of hypothalamus spermatid seminiferous tubule median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity zinc ion binding glutaminyl-peptide cyclotransferase activity acyltransferase activity metal ion binding Cellular component extracellular exosome extracellular region specific granule lumen tertiary granule lumen ficolin-1-rich granule lumen Biological process peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25797 70536 Ensembl ENSG00000115828 ENSMUSG00000024084 UniProt Q16769 Q9CYK2 RefSeq (mRNA) NM_012413 NM_027455 NM_001316729 RefSeq (protein) NP_036545 NP_001303658 NP_081731 Location (UCSC) Chr 2: 37.34 – 37.37 Mb Chr 17: 79.36 – 79.4 Mb PubMed search [3] [4]
Wikidata
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This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.^[6]