RAB7B

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.^[5]

RAB7B
Identifiers
Aliases	RAB7B, RAB7, member RAS oncogene family
External IDs	MGI: 2442295; HomoloGene: 64833; GeneCards: RAB7B; OMA:RAB7B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 205,976,740 bp[1] End 206,003,461 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 131,616,433 bp[2] End 131,643,177 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of abdomen gingival epithelium skin of leg skin of thigh mucosa of esophagus gallbladder skin of hip right coronary artery vagina Top expressed in stroma of bone marrow lip skin of back calvaria epidermis esophagus skin of abdomen umbilical cord cornea ankle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding GTPase activity Cellular component endosome late endosome Golgi apparatus trans-Golgi network lysosome phagocytic vesicle membrane phagocytic vesicle membrane cytoplasmic vesicle late endosome membrane vacuolar membrane Biological process protein transport negative regulation of toll-like receptor 9 signaling pathway late endosome to Golgi transport positive regulation of NF-kappaB transcription factor activity positive regulation of megakaryocyte differentiation negative regulation of toll-like receptor 4 signaling pathway positive regulation of interleukin-6 production cellular response to interferon-gamma intracellular protein transport endosome to lysosome transport Rab protein signal transduction phagosome-lysosome fusion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338382 226421 Ensembl ENSG00000276600 ENSMUSG00000052688 UniProt Q96AH8 Q8VEA8 RefSeq (mRNA) NM_001164522 NM_001304839 NM_177403 NM_145509 NM_001311096 RefSeq (protein) NP_001157994 NP_001291768 NP_796377 NP_001298025 NP_663484 Location (UCSC) Chr 1: 205.98 – 206 Mb Chr 1: 131.62 – 131.64 Mb PubMed search [3] [4]
Wikidata
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Function

Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells.^[6] By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.^[6]