RAB8A

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.^[5][6][7]

RAB8A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QBT, 3TNF, 4LHV, 4LHW, 4LHX, 4LHY, 4LHZ, 4LI0
Identifiers
Aliases	RAB8A, MEL, RAB8, member RAS oncogene family
External IDs	OMIM: 165040; MGI: 96960; HomoloGene: 100934; GeneCards: RAB8A; OMA:RAB8A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 16,111,889 bp[1] End 16,134,234 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.84 cM Start 72,915,044 bp[2] End 72,937,748 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte mucosa of ileum bone marrow cell duodenum mucosa of sigmoid colon jejunal mucosa blood epithelium of colon granulocyte human penis Top expressed in granulocyte molar yolk sac tibiofemoral joint thymus duodenum right kidney epithelium of small intestine ventricular zone medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding myosin V binding protein binding protein kinase binding GTPase activity Cellular component cytoplasm ciliary basal body recycling endosome cytosol endosome centrosome phagocytic vesicle membrane Golgi apparatus cell projection membrane postsynaptic density synaptic vesicle Golgi membrane cilium ciliary base soma dendrite phagocytic vesicle centriole extracellular exosome cytoskeleton cytoplasmic vesicle extracellular matrix plasma membrane trans-Golgi network transport vesicle trans-Golgi network membrane dendritic spine recycling endosome membrane non-motile cilium secretory granule membrane midbody synapse glutamatergic synapse Biological process regulation of long-term neuronal synaptic plasticity regulation of protein transport axonogenesis vesicle docking involved in exocytosis protein secretion regulation of protein localization cell projection organization G2/M transition of mitotic cell cycle Golgi vesicle fusion to target membrane protein transport protein localization to plasma membrane cellular response to insulin stimulus cilium assembly ciliary basal body-plasma membrane docking neurotransmitter receptor transport to postsynaptic membrane regulation of autophagy autophagy post-translational protein modification regulation of exocytosis transport intracellular protein transport Rab protein signal transduction neurotransmitter receptor transport, endosome to postsynaptic membrane vesicle-mediated transport in synapse Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4218 17274 Ensembl ENSG00000167461 ENSMUSG00000003037 UniProt P61006 P55258 RefSeq (mRNA) NM_005370 NM_023126 RefSeq (protein) NP_005361 NP_005361.2 NP_075615 Location (UCSC) Chr 19: 16.11 – 16.13 Mb Chr 8: 72.92 – 72.94 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrated. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.^[7]

Interactions

RAB8A has been shown to interact with Optineurin^[8] and MAP4K2.^[9]