RAE1

mRNA export factor is a protein that in humans is encoded by the RAE1 gene.^[5][6][7]

RAE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MMY, 4OWR
Identifiers
Aliases	RAE1, MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1, ribonucleic acid export 1, Gle2
External IDs	OMIM: 603343; MGI: 1913929; HomoloGene: 2676; GeneCards: RAE1; OMA:RAE1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.31 Start 57,351,223 bp[1] End 57,379,211 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 95.66 cM Start 172,841,910 bp[2] End 172,857,532 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm left testis right testis tendon of biceps brachii internal globus pallidus embryo trabecular bone ganglionic eminence bone marrow Top expressed in otic placode spermatocyte saccule otic vesicle spermatid epiblast zygote embryo mandibular prominence ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding RNA binding protein binding ubiquitin binding Cellular component cytoplasm nuclear pore nucleus nuclear envelope fibrillar center mitotic spindle pole spindle pole cytoskeleton host cell Biological process cellular response to organic cyclic compound viral process regulation of mitotic spindle organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery RNA export from nucleus protein import into nucleus cell cycle cell division mRNA export from nucleus regulation of glycolytic process tRNA export from nucleus protein sumoylation viral transcription regulation of gene silencing by miRNA intracellular transport of virus regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8480 66679 Ensembl ENSG00000101146 ENSMUSG00000027509 UniProt P78406 Q8C570 RefSeq (mRNA) NM_001015885 NM_003610 NM_175112 RefSeq (protein) NP_001015885 NP_003601 NP_780321 Location (UCSC) Chr 20: 57.35 – 57.38 Mb Chr 2: 172.84 – 172.86 Mb PubMed search [3] [4]
Wikidata
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Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.^[7]

Interactions

RAE1 has been shown to interact with NUP98.^[8]