RAMP1

Receptor activity modifying protein 1 is a protein that in humans is encoded by the RAMP1 gene.^[5][6]

RAMP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YX8, 3N7P, 3N7R, 3N7S, 4RWG
Identifiers
Aliases	RAMP1, entrez:10267, receptor activity modifying protein 1
External IDs	OMIM: 605153; MGI: 1858418; HomoloGene: 4275; GeneCards: RAMP1; OMA:RAMP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 237,858,893 bp[1] End 237,912,106 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 D|1 46.08 cM Start 91,107,544 bp[2] End 91,152,918 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of uterus ascending aorta canal of the cervix Descending thoracic aorta right coronary artery left uterine tube apex of heart popliteal artery tibial arteries gastric mucosa Top expressed in temporal muscle soleus muscle sternocleidomastoid muscle crypt of lieberkuhn of small intestine entorhinal cortex perirhinal cortex olfactory tubercle seminal vesicula nucleus accumbens masseter muscle More reference expression data BioGPS n/a
Gene ontology Molecular function coreceptor activity calcitonin receptor activity calcitonin receptor binding protein binding calcitonin gene-related peptide receptor activity amylin receptor activity calcitonin gene-related peptide binding Cellular component integral component of membrane membrane plasma membrane receptor complex integral component of plasma membrane intracellular anatomical structure cell surface extracellular space amylin receptor complex 1 CGRP receptor complex Biological process G protein-coupled receptor signaling pathway positive regulation of protein glycosylation regulation of G protein-coupled receptor signaling pathway receptor internalization angiogenesis transport protein transport protein localization to plasma membrane intracellular protein transport calcium ion transport adenylate cyclase-activating G protein-coupled receptor signaling pathway cellular response to hormone stimulus amylin receptor signaling pathway calcitonin gene-related peptide receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10267 51801 Ensembl ENSG00000132329 ENSMUSG00000034353 UniProt O60894 Q9WTJ5 RefSeq (mRNA) NM_001308353 NM_005855 NM_001168392 NM_016894 NM_178401 RefSeq (protein) NP_001295282 NP_005846 NP_001161864 NP_058590 NP_848488 Location (UCSC) Chr 2: 237.86 – 237.91 Mb Chr 1: 91.11 – 91.15 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CALCRL) to the plasma membrane. CALCRL, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In combination with the RAMP1 protein, CALCRL functions as the CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.^[5] The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY₁ ^[7]

See also

• Receptor activity-modifying protein