RAMP2

Receptor activity modifying protein 2, also known as RAMP2, is a protein which in humans is encoded by the RAMP2 gene.^[5][6]

RAMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RWF, 2XVT, 3AQE, 3AQF
Identifiers
Aliases	RAMP2, entrez:10266, receptor activity modifying protein 2
External IDs	OMIM: 605154; MGI: 1859650; HomoloGene: 4274; GeneCards: RAMP2; OMA:RAMP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,758,447 bp[1] End 42,763,041 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 64.47 cM Start 101,136,854 bp[2] End 101,150,372 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung gastric mucosa apex of heart upper lobe of left lung tibial nerve canal of the cervix subcutaneous adipose tissue right coronary artery left uterine tube right lobe of thyroid gland Top expressed in right lung right lung lobe left lung left lung lobe external carotid artery atrium internal carotid artery carotid body endocardial cushion yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function coreceptor activity protein binding adrenomedullin receptor activity amylin receptor activity adrenomedullin binding Cellular component cytoplasm integral component of membrane membrane plasma membrane receptor complex integral component of plasma membrane cell surface clathrin-coated pit lysosome amylin receptor complex 2 adrenomedullin receptor complex Biological process negative regulation of endothelial cell apoptotic process G protein-coupled receptor signaling pathway response to estradiol response to hypoxia regulation of G protein-coupled receptor signaling pathway adherens junction assembly response to progesterone female pregnancy receptor internalization sprouting angiogenesis basement membrane assembly positive regulation of angiogenesis vasculogenesis regulation of blood pressure heart development cellular response to hormone stimulus positive regulation of gene expression positive regulation of vasculogenesis angiogenesis bicellular tight junction assembly transport protein transport cellular response to vascular endothelial growth factor stimulus intracellular protein transport protein localization to plasma membrane vascular associated smooth muscle cell development calcium ion transport negative regulation of vascular permeability cAMP biosynthetic process adenylate cyclase-activating G protein-coupled receptor signaling pathway amylin receptor signaling pathway adrenomedullin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10266 54409 Ensembl ENSG00000131477 ENSMUSG00000001240 UniProt O60895 Q9WUP0 RefSeq (mRNA) NM_005854 NM_019444 RefSeq (protein) NP_005845 NP_062317 Location (UCSC) Chr 17: 42.76 – 42.76 Mb Chr 11: 101.14 – 101.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N-terminus and a cytoplasmic C-terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.^[5]