RAP1B

Ras-related protein Rap-1b, also known as GTP-binding protein smg p21B, is a protein that in humans is encoded by the RAP1B gene.^[5][6][7][8]

RAP1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BRW, 3CF6, 4DXA, 4HDO, 4HDQ, 4M8N, 4MGI, 4MGK, 4MGY, 4MGZ, 4MH0
Identifiers
Aliases	RAP1B, K-REV, RAL1B, member of RAS oncogene family
External IDs	OMIM: 179530; MGI: 894315; HomoloGene: 68719; GeneCards: RAP1B; OMA:RAP1B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 68,610,855 bp[1] End 68,671,901 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 117,649,776 bp[2] End 117,681,940 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Achilles tendon lymph node granulocyte appendix endometrium smooth muscle tissue gonad tibial arteries bone marrow Top expressed in left lung lobe blood decidua stroma of bone marrow right lung lobe endocardial cushion ureter dermis gastrula endothelial cell of lymphatic vessel More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GDP binding protein-containing complex binding GTP binding protein binding GTPase activity Cellular component cytoplasm cytosol membrane cell-cell junction plasma membrane lipid droplet intracellular anatomical structure cell junction membrane raft extracellular exosome azurophil granule membrane Biological process establishment of endothelial barrier microvillus assembly regulation of cell junction assembly Rap protein signal transduction regulation of establishment of cell polarity cellular response to cAMP signal transduction neutrophil degranulation interleukin-12-mediated signaling pathway small GTPase mediated signal transduction cell population proliferation response to carbohydrate negative regulation of calcium ion-dependent exocytosis positive regulation of ERK1 and ERK2 cascade cellular response to organic cyclic compound cellular response to gonadotropin-releasing hormone negative regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5908 215449 Ensembl ENSG00000127314 ENSMUSG00000052681 UniProt P61224 Q99JI6 RefSeq (mRNA) NM_015646 NM_001010942 NM_001251917 NM_001251918 NM_001251921 NM_001251922 NM_024457 RefSeq (protein) NP_001010942 NP_001238846 NP_001238847 NP_001238850 NP_001238851 NP_056461 NP_001010942.1 NP_056461.1 NP_077777 Location (UCSC) Chr 12: 68.61 – 68.67 Mb Chr 10: 117.65 – 117.68 Mb PubMed search [3] [4]
Wikidata
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