RAP1GAP

Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene.^[5][6]

RAP1GAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SRQ, 3BRW
Identifiers
Aliases	RAP1GAP, RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP, RAP1 GTPase activating protein
External IDs	OMIM: 600278; MGI: 109338; HomoloGene: 2163; GeneCards: RAP1GAP; OMA:RAP1GAP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 21,596,215 bp[1] End 21,669,363 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 70.02 cM Start 137,664,726 bp[2] End 137,729,861 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla left lobe of thyroid gland nucleus accumbens right lobe of thyroid gland parotid gland putamen caudate nucleus middle frontal gyrus right frontal lobe external globus pallidus Top expressed in superior frontal gyrus habenula primary visual cortex nucleus accumbens nucleus of stria terminalis perirhinal cortex olfactory tubercle entorhinal cortex parotid gland central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity GTPase regulator activity protein binding GTPase activity GTPase activator activity Cellular component Golgi apparatus membrane Golgi membrane cytosol Biological process negative regulation of microvillus assembly regulation of GTPase activity positive regulation of GTPase activity regulation of small GTPase mediated signal transduction signal transduction axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5909 110351 Ensembl ENSG00000076864 ENSMUSG00000041351 UniProt P47736 A2ALS5 RefSeq (mRNA) NM_001145657 NM_001145658 NM_002885 NM_001330383 NM_001350524 NM_001350525 NM_001350526 NM_001350527 NM_001350528 NM_001081155 NM_001256218 NM_029563 NM_001331215 RefSeq (protein) NP_001139129 NP_001139130 NP_001317312 NP_002876 NP_001337453 NP_001337454 NP_001337455 NP_001337456 NP_001337457 NP_001074624 NP_001243147 NP_001318144 NP_083839 NP_001366162 NP_001366163 NP_001366164 NP_001366165 Location (UCSC) Chr 1: 21.6 – 21.67 Mb Chr 4: 137.66 – 137.73 Mb PubMed search [3] [4]
Wikidata
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Interactions

RAP1GAP has been shown to interact with MLLT4.^[7]