RAP1GDS1

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.^[5][6][7]

RAP1GDS1
Identifiers
Aliases	RAP1GDS1, GDS1, SmgGDS, Rap1 GTPase-GDP dissociation stimulator 1
External IDs	OMIM: 179502; MGI: 2385189; HomoloGene: 41422; GeneCards: RAP1GDS1; OMA:RAP1GDS1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q23 Start 98,261,384 bp[1] End 98,443,861 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H1 Start 138,631,663 bp[2] End 138,780,962 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pons pars compacta trigeminal ganglion pars reticulata middle temporal gyrus spinal ganglia superior vestibular nucleus sperm corpus callosum Top expressed in medial dorsal nucleus medial geniculate nucleus lateral geniculate nucleus perirhinal cortex inferior colliculi olfactory epithelium visual cortex pontine nuclei primary motor cortex CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytosol extracellular exosome endoplasmic reticulum mitochondrion Biological process negative regulation of endoplasmic reticulum calcium ion concentration positive regulation of mitochondrial calcium ion concentration vascular associated smooth muscle contraction myosin filament assembly small GTPase mediated signal transduction positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5910 229877 Ensembl ENSG00000138698 ENSMUSG00000028149 UniProt P52306 E9Q912 RefSeq (mRNA) NM_001100426 NM_001100427 NM_001100428 NM_001100429 NM_001100430 NM_021159 NM_001040690 NM_001286759 NM_145544 NM_001356388 RefSeq (protein) NP_001093896 NP_001093897 NP_001093898 NP_001093899 NP_001093900 NP_066982 NP_001035780 NP_001273688 NP_001343317 NP_663519 Location (UCSC) Chr 4: 98.26 – 98.44 Mb Chr 3: 138.63 – 138.78 Mb PubMed search [3] [4]
Wikidata
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Interactions

RAP1GDS1 has been shown to interact with KIFAP3,^[8] HRAS^[9] and RHOA.^[9]