RARRES3

Retinoic acid receptor responder protein 3 is a protein that in humans is encoded by the RARRES3 gene.^[3][4]

PLAAT4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2LKT, 2MY9
Identifiers
Aliases	PLAAT4, HRASLS4, HRSL4, PLA1/2-3, RIG1, TIG3, retinoic acid receptor responder 3, PLAAT-4, RARRES3, phospholipase A and acyltransferase 4
External IDs	OMIM: 605092; HomoloGene: 48290; GeneCards: PLAAT4; OMA:PLAAT4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 63,536,808 bp[1] End 63,546,462 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte nasal epithelium olfactory zone of nasal mucosa palpebral conjunctiva epithelium of bronchus bronchial epithelial cell upper lobe of left lung right uterine tube lymph node right lung n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding hydrolase activity phospholipase A2 activity acyltransferase activity phospholipase A1 activity N-acyltransferase activity phosphatidylserine 1-acylhydrolase activity 1-acyl-2-lysophosphatidylserine acylhydrolase activity Cellular component integral component of membrane membrane cytosol Biological process lipid catabolic process lipid metabolism negative regulation of cell population proliferation phospholipid metabolic process phosphatidylethanolamine acyl-chain remodeling N-acylphosphatidylethanolamine metabolic process positive regulation of keratinocyte differentiation positive regulation of protein-glutamine gamma-glutamyltransferase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5920 n/a Ensembl ENSG00000133321 n/a UniProt Q9UL19 n/a RefSeq (mRNA) NM_004585 n/a RefSeq (protein) NP_004576 n/a Location (UCSC) Chr 11: 63.54 – 63.55 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.^[4]

Interactions

RARRES3 has been shown to interact with RNF135.^[5]