RASA3

Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene.^[5][6][7]

RASA3
Identifiers
Aliases	RASA3, GAP1IP4BP, GAPIII, RAS p21 protein activator 3
External IDs	OMIM: 605182; MGI: 1197013; HomoloGene: 7217; GeneCards: RASA3; OMA:RASA3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 113,977,783 bp[1] End 114,132,623 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 6.29 cM Start 13,616,948 bp[2] End 13,727,603 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte stromal cell of endometrium sural nerve monocyte blood subcutaneous adipose tissue lymph node right uterine tube canal of the cervix appendix Top expressed in mesenteric lymph nodes blood stroma of bone marrow granulocyte spleen tibiofemoral joint calvaria subcutaneous adipose tissue white adipose tissue cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-release channel activity metal ion binding GTPase activator activity Cellular component cytoplasm cytosol membrane intrinsic component of the cytoplasmic side of the plasma membrane plasma membrane Biological process intracellular signal transduction regulation of GTPase activity MAPK cascade signal transduction positive regulation of GTPase activity release of sequestered calcium ion into cytosol negative regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22821 19414 Ensembl ENSG00000280477 ENSG00000185989 ENSMUSG00000031453 UniProt Q14644 Q60790 RefSeq (mRNA) NM_007368 NM_001320821 NM_001320822 NM_009025 RefSeq (protein) NP_001307750 NP_001307751 NP_031394 NP_033051 Location (UCSC) Chr 13: 113.98 – 114.13 Mb Chr 8: 13.62 – 13.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.^[7] It has been shown that RASA3 promotes a shift from noncanonical to canonical TGF-β signaling through SMAD3 in B cells.^[8]

Interactions

RASA3 has been shown to interact with HCK.^[9]