RASGRP3

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.^[5][6][7]

RASGRP3
Identifiers
Aliases	RASGRP3, GRP3, RAS guanyl releasing protein 3
External IDs	OMIM: 609531; MGI: 3028579; HomoloGene: 15019; GeneCards: RASGRP3; OMA:RASGRP3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.3 Start 33,436,324 bp[1] End 33,564,750 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E2 Start 75,742,891 bp[2] End 75,836,049 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum inferior ganglion of vagus nerve C1 segment subthalamic nucleus internal globus pallidus superior vestibular nucleus Pons left ventricle lymph node muscle of thigh Top expressed in iris retinal pigment epithelium endothelial cell of lymphatic vessel mesenteric lymph nodes lumbar subsegment of spinal cord medial head of gastrocnemius muscle triceps brachii muscle sternocleidomastoid muscle left lung lobe primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding guanyl-nucleotide exchange factor activity GTPase activator activity signal transducer activity metal ion binding kinase binding protein binding diacylglycerol binding Cellular component cytoplasm plasma membrane integral component of plasma membrane perinuclear region of cytoplasm guanyl-nucleotide exchange factor complex intracellular anatomical structure Biological process intracellular signal transduction regulation of GTPase activity small GTPase mediated signal transduction MAPK cascade positive regulation of GTPase activity Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25780 240168 Ensembl ENSG00000152689 ENSMUSG00000071042 UniProt Q8IV61 Q6NZH9 RefSeq (mRNA) NM_001139488 NM_015376 NM_170672 NM_001349975 NM_001349976 NM_001349977 NM_001349978 NM_001349979 NM_001349980 NM_001349981 NM_001166493 NM_207246 NM_001360103 RefSeq (protein) NP_001132960 NP_056191 NP_733772 NP_001336904 NP_001336905 NP_001336906 NP_001336907 NP_001336908 NP_001336909 NP_001336910 NP_001159965 NP_997129 NP_001347032 Location (UCSC) Chr 2: 33.44 – 33.56 Mb Chr 17: 75.74 – 75.84 Mb PubMed search [3] [4]
Wikidata
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Function

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).^[7]

Interactions

RASGRP3 has been shown to interact with PRKCD.^[8]