RASSF2

Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.^[5][6][7]

RASSF2
Identifiers
Aliases	RASSF2, CENP-34, RASFADIN, Ras association domain family member 2
External IDs	OMIM: 609492; MGI: 2442060; HomoloGene: 22840; GeneCards: RASSF2; OMA:RASSF2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 4,780,023 bp[1] End 4,823,608 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F2 Start 131,831,335 bp[2] End 131,872,178 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve subthalamic nucleus C1 segment external globus pallidus medulla oblongata corpus callosum pars reticulata superior vestibular nucleus internal globus pallidus middle frontal gyrus Top expressed in meninges granulocyte thymus stroma of bone marrow mesenteric lymph nodes lumbar subsegment of spinal cord spleen blood optic nerve uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase activity Cellular component cytoplasm nucleus chromosome, centromeric region kinetochore chromosome nucleoplasm Golgi apparatus cytosol plasma membrane protein-containing complex Biological process positive regulation of JNK cascade positive regulation of protein autophosphorylation skeletal system development regulation of osteoclast differentiation negative regulation of peptidyl-serine phosphorylation regulation of osteoblast differentiation regulation of NIK/NF-kappaB signaling homeostasis of number of cells bone remodeling ossification negative regulation of NIK/NF-kappaB signaling epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade positive regulation of apoptotic process signal transduction positive regulation of protein kinase activity protein stabilization cell cycle protein phosphorylation regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9770 215653 Ensembl ENSG00000101265 ENSMUSG00000027339 UniProt P50749 Q8BMS9 RefSeq (mRNA) NM_014737 NM_170774 NM_170773 NM_175445 NM_001362866 RefSeq (protein) NP_055552 NP_739580 NP_780654 NP_001349795 Location (UCSC) Chr 20: 4.78 – 4.82 Mb Chr 2: 131.83 – 131.87 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.^[7]

Interactions

RASSF2 has been shown to interact with KRAS.^[8]