RBBP9

Putative hydrolase RBBP9 is an enzyme that in humans is encoded by the RBBP9 gene.^[5][6][7]

RBBP9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QS9
Identifiers
Aliases	RBBP9, BOG, RBBP10, retinoblastoma binding protein 9, RB binding protein 9, serine hydrolase
External IDs	OMIM: 602908; MGI: 1347074; HomoloGene: 4816; GeneCards: RBBP9; OMA:RBBP9 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.23 Start 18,486,540 bp[1] End 18,497,225 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G1 Start 144,384,185 bp[2] End 144,392,789 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium olfactory zone of nasal mucosa bronchial epithelial cell ventricular zone skin of thigh ganglionic eminence mucosa of paranasal sinus stromal cell of endometrium palpebral conjunctiva endothelial cell Top expressed in vestibular sensory epithelium right kidney left lung lobe tail of embryo olfactory epithelium epithelium of lens seminal vesicula genital tubercle sciatic nerve ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding hydrolase activity Cellular component nucleus nucleoplasm cytoplasm Biological process regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10741 26450 Ensembl ENSG00000089050 ENSMUSG00000027428 UniProt O75884 O88851 RefSeq (mRNA) NM_006606 NM_153328 NM_015754 RefSeq (protein) NP_006597 NP_056569 Location (UCSC) Chr 20: 18.49 – 18.5 Mb Chr 2: 144.38 – 144.39 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate.^[7]

Interactions

RBBP9 has been shown to interact with Retinoblastoma protein.^[5]