RBM23

Probable RNA-binding protein 23 is a protein that in humans is encoded by the RBM23 gene.^[3]

RBM23
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2CQ4, 2DNZ
Identifiers
Aliases	RBM23, CAPERbeta, RNPC4, PP239, RNA binding motif protein 23
External IDs	HomoloGene: 56796; GeneCards: RBM23; OMA:RBM23 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 22,893,204 bp[1] End 22,919,182 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon right uterine tube left ovary right lobe of thyroid gland islet of Langerhans body of uterus ventricular zone left lobe of thyroid gland right ovary monocyte n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding nucleic acid binding mRNA binding U1 snRNP binding Cellular component membrane nucleus cytoplasmic stress granule ribonucleoprotein complex Biological process mRNA processing 3'-UTR-mediated mRNA destabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55147 n/a Ensembl ENSG00000100461 n/a UniProt Q86U06 n/a RefSeq (mRNA) NM_001077351 NM_001077352 NM_001308044 NM_018107 NM_001352762 NM_001352763 NM_001352764 NM_001352765 NM_001352766 n/a RefSeq (protein) NP_001070819 NP_001070820 NP_001294973 NP_060577 NP_001339691 NP_001339692 NP_001339693 NP_001339694 NP_001339695 n/a Location (UCSC) Chr 14: 22.89 – 22.92 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene.^[3]