RBM3

Putative RNA-binding protein 3 is a protein that in humans is encoded by the RBM3 gene.^[4][5]

RBM3
Identifiers
Aliases	RBM3, IS1-RNPL, RNPL, RNA binding motif (RNP1, RRM) protein 3, RNA binding motif protein 3
External IDs	OMIM: 300027; MGI: 3642874; HomoloGene: 31404; GeneCards: RBM3; OMA:RBM3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 48,574,449 bp[1] End 48,581,162 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon human penis monocyte synovial joint nipple gastric mucosa saphenous vein skin of leg body of pancreas olfactory zone of nasal mucosa n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding mRNA 3'-UTR binding poly(U) RNA binding translation repressor activity ribosomal large subunit binding small ribosomal subunit rRNA binding Cellular component cytoplasm large ribosomal subunit dendrite cell projection nucleolus nucleus nucleoplasm spliceosomal complex ribonucleoprotein complex Biological process RNA processing regulation of translation positive regulation of translation response to cold negative regulation of translation positive regulation of mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5935 100043257 Ensembl ENSG00000102317 n/a UniProt P98179 n/a RefSeq (mRNA) NM_001017430 NM_001017431 NM_006743 XM_036156140 RefSeq (protein) NP_006734 n/a Location (UCSC) Chr X: 48.57 – 48.58 Mb n/a PubMed search [2] [3]
Wikidata
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Function

This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5] RBM3 contains a poison exon whose inclusion is lowered during hypothermia.^[6]

RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apoptotic effects.^[7] According to antibody-based profiling and transcriptomics analysis, RBM3 protein is present in all analysed human tissues^[8] and based on confocal microscopy mainly localised to the nucleoplasm.^[9]

Clinical significance

RBM3 is a proto-oncogene that is associated with tumor progression and metastasis and is a potential cancer biomarker.^[7] Based on patient survival data, high levels of RBM3 protein in tumor cells is a favourable prognostic biomarker in colorectal cancer.^[10]