RBP1

Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene.^[5][6][7]

RBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5HA1, 5HBS, 5H8T, 5H9A
Identifiers
Aliases	RBP1, CRABP-I, CRBP, CCRBPI, RBPC, retinol binding protein 1
External IDs	OMIM: 180260; MGI: 97876; HomoloGene: 2175; GeneCards: RBP1; OMA:RBP1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q23 Start 139,517,434 bp[1] End 139,539,829 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E3.3|9 51.36 cM Start 98,305,014 bp[2] End 98,328,628 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium right uterine tube body of pancreas left ovary right adrenal gland right adrenal cortex anterior pituitary left adrenal gland left adrenal cortex decidua Top expressed in choroid plexus of fourth ventricle vestibular sensory epithelium optic nerve retinal pigment epithelium medial ganglionic eminence endocardial cushion efferent ductule lactiferous gland external carotid artery internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding retinol binding retinoid binding retinal binding all-trans-retinol binding Cellular component nucleoplasm cytoplasm cytosol lipid droplet Biological process retinoic acid biosynthetic process retinoid metabolic process vitamin A metabolic process lipid homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5947 19659 Ensembl ENSG00000114115 ENSMUSG00000046402 UniProt P09455 Q00915 RefSeq (mRNA) NM_002899 NM_001130992 NM_001130993 NM_001365940 NM_011254 RefSeq (protein) NP_001124464 NP_001124465 NP_002890 NP_001352869 NP_035384 Location (UCSC) Chr 3: 139.52 – 139.54 Mb Chr 9: 98.31 – 98.33 Mb PubMed search [3] [4]
Wikidata
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Function

RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues, respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene.^[5]

Clinical significance

Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiative state of endometrial cells through the regulation of bioavailability of retinol. On the converse, loss of CRBP-1 is associated with development of endometrial cancer.^[8]