RBP2

Retinol-binding protein 2 (RBP2) is a protein that in humans is encoded by the RBP2 gene.^[5][6][7]

RBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RCQ, 2RCT, 4EDE, 4EEJ, 4EFG, 4EXZ, 4GKC, 4QYN, 4QYP, 4QZT, 4QZU, 4RUU, 4ZGU, 4ZH9, 4ZCB, 4ZH6, 4ZJ0, 4ZR2
Identifiers
Aliases	RBP2, CRABP-II, CCRBPII, RBPC2, retinol binding protein 2
External IDs	OMIM: 180280; MGI: 97877; HomoloGene: 3070; GeneCards: RBP2; OMA:RBP2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q23 Start 139,452,884 bp[1] End 139,480,747 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E3.3|9 51.37 cM Start 98,368,168 bp[2] End 98,391,834 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of ileum duodenum buccal mucosa cell testicle right lung amniotic fluid right uterine tube mucosa of transverse colon upper lobe of left lung Top expressed in duodenum esophagus pyloric antrum jejunum ileum lip mucous cell of stomach yolk sac migratory enteric neural crest cell corneal stroma More reference expression data BioGPS n/a
Gene ontology Molecular function lipid binding retinol binding retinoid binding retinal binding Cellular component cytoplasm cytosol Biological process retinoid metabolic process epidermis development vitamin A metabolic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5948 19660 Ensembl ENSG00000114113 ENSMUSG00000032454 UniProt P50120 Q08652 RefSeq (mRNA) NM_004164 NM_009034 RefSeq (protein) NP_004155 NP_033060 Location (UCSC) Chr 3: 139.45 – 139.48 Mb Chr 9: 98.37 – 98.39 Mb PubMed search [3] [4]
Wikidata
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Function

RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.^[7]