RBPMS

RNA-binding protein with multiple splicing is a protein that in humans is encoded by the RBPMS gene.^[5][6]

RBPMS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5DET, 5CYJ
Identifiers
Aliases	RBPMS, HERMES, RNA binding protein with multiple splicing, RNA binding protein, mRNA processing factor
External IDs	OMIM: 601558; MGI: 1334446; HomoloGene: 38238; GeneCards: RBPMS; OMA:RBPMS - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p12 Start 30,384,511 bp[1] End 30,572,256 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A4 Start 34,272,671 bp[2] End 34,419,891 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries gastric mucosa right coronary artery thoracic aorta ascending aorta left coronary artery Descending thoracic aorta muscle layer of sigmoid colon body of uterus Top expressed in ascending aorta aortic valve atrium interventricular septum tail of embryo tunica media of zone of aorta embryo genital tubercle zygote right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein binding poly(A) binding nucleic acid binding protein homodimerization activity RNA binding U1 snRNA binding snRNA stem-loop binding mRNA binding Cellular component nucleus nucleoplasm P-body cytoplasmic stress granule U1 snRNP cytoplasm cytosol Biological process positive regulation of pathway-restricted SMAD protein phosphorylation RNA processing regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of SMAD protein signal transduction response to oxidative stress mRNA splicing, via spliceosome positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11030 19663 Ensembl ENSG00000157110 ENSMUSG00000031586 UniProt Q93062 Q9WVB0 RefSeq (mRNA) NM_001008710 NM_001008711 NM_001008712 NM_006867 NM_001042674 NM_001042675 NM_001286168 NM_019733 RefSeq (protein) NP_001008710 NP_001008711 NP_001008712 NP_006858 NP_001036139 NP_001036140 NP_001273097 NP_062707 Location (UCSC) Chr 8: 30.38 – 30.57 Mb Chr 8: 34.27 – 34.42 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the RRM family of RNA-binding proteins. The RRM domain is between 80-100 amino acids in length and family members contain one to four copies of the domain. The RRM domain consists of two short stretches of conserved sequence called RNP1 and RNP2, as well as a few highly conserved hydrophobic residues. The protein encoded by this gene has a single, putative RRM domain in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]

It is uniquely expressed in retinal ganglion cells in the mammalian retina,^[7] for reasons unknown.

Interactions

RBPMS has been shown to interact with SMUG1.^[8]