RC3H1

Ring finger and CCCH-type domains 1, also known as Roquin-1, is a protein that in humans is encoded by the RC3H1 gene.^[5]

RC3H1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3X1O, 4QIK, 4QIL, 4ULW, 4YWQ
Identifiers
Aliases	RC3H1, RNF198, ROQUIN, ring finger and CCCH-type domains 1, FHL6, IMDSHY
External IDs	OMIM: 609424; MGI: 2685397; HomoloGene: 19036; GeneCards: RC3H1; OMA:RC3H1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.1 Start 173,931,084 bp[1] End 174,022,357 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.1 Start 160,733,988 bp[2] End 160,802,548 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle skin of thigh mucosa of ileum deltoid muscle buccal mucosa cell skin of hip skin of arm pancreatic epithelial cell cardiac muscle tissue of right atrium trabecular bone Top expressed in hand aortic valve ascending aorta otolith organ utricle fossa condyle facial motor nucleus Paneth cell conjunctival fornix More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin protein ligase activity metal ion binding mRNA binding RNA stem-loop binding mRNA 3'-UTR binding RNA binding double-stranded RNA binding ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity miRNA binding Cellular component cytoplasm P-body cytoplasmic stress granule Biological process regulation of T cell proliferation regulation of T cell activation B cell homeostasis spleen development positive regulation of NIK/NF-kappaB signaling T cell homeostasis T cell proliferation regulation of gene expression lymph node development T follicular helper cell differentiation negative regulation of T-helper cell differentiation regulation of mRNA stability positive regulation of mRNA catabolic process regulation of germinal center formation posttranscriptional regulation of gene expression negative regulation of germinal center formation negative regulation of B cell proliferation cellular response to interleukin-1 protein ubiquitination nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay P-body assembly regulation of T cell receptor signaling pathway nuclear-transcribed mRNA catabolic process negative regulation of activated T cell proliferation 3'-UTR-mediated mRNA destabilization protein polyubiquitination T cell receptor signaling pathway negative regulation of T-helper 17 cell differentiation regulation of miRNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 149041 381305 Ensembl ENSG00000135870 ENSMUSG00000040423 UniProt Q5TC82 Q4VGL6 RefSeq (mRNA) NM_001300850 NM_001300851 NM_001300852 NM_172071 NM_001024952 RefSeq (protein) NP_001287779 NP_001287780 NP_001287781 NP_742068 NP_001287779.1 NP_001020123 Location (UCSC) Chr 1: 173.93 – 174.02 Mb Chr 1: 160.73 – 160.8 Mb PubMed search [3] [4]
Wikidata
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Function

The consensus primary sequence and secondary structure for the Roquin-1 (RC3H1) binding site (also called constitutive decay element (CDE)).

This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].