RCC2

Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene.^[5][6][7]

RCC2
Identifiers
Aliases	RCC2, TD-60, regulator of chromosome condensation 2
External IDs	OMIM: 609587; MGI: 1919784; HomoloGene: 10282; GeneCards: RCC2; OMA:RCC2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.13 Start 17,406,760 bp[1] End 17,439,677 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 140,427,852 bp[2] End 140,450,531 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence lymph node monocyte skin of abdomen stromal cell of endometrium ventricular zone skin of leg appendix granulocyte gonad Top expressed in ventricular zone primitive streak somite epiblast thymus abdominal wall fetal liver hematopoietic progenitor cell ganglionic eminence medial ganglionic eminence lip More reference expression data BioGPS n/a
Gene ontology Molecular function protein domain specific binding microtubule binding small GTPase binding protein binding protein kinase binding RNA binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol early endosome membrane membrane plasma membrane spindle chromosome, centromeric core domain chromosome mitotic spindle midzone midbody nucleolus microtubule chromosome, centromeric region cytoskeleton nucleus Biological process regulation of cell migration activation of GTPase activity establishment of protein localization cell division chromosome passenger complex localization to kinetochore positive regulation of attachment of spindle microtubules to kinetochore focal adhesion assembly negative regulation of GTPase activity regulation of ruffle assembly integrin-mediated signaling pathway positive regulation of G2/M transition of mitotic cell cycle cell cycle negative regulation of substrate adhesion-dependent cell spreading regulation of fibroblast migration negative regulation of focal adhesion assembly sister chromatid cohesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55920 108911 Ensembl ENSG00000281540 ENSG00000179051 ENSMUSG00000040945 UniProt Q9P258 Q8BK67 RefSeq (mRNA) NM_018715 NM_001136204 NM_173867 RefSeq (protein) NP_001129676 NP_061185 NP_001129676.1 NP_061185.1 NP_776292 Location (UCSC) Chr 1: 17.41 – 17.44 Mb Chr 4: 140.43 – 140.45 Mb PubMed search [3] [4]
Wikidata
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Function

RCC2 has structural similarity to RCC1, and has been shown to have weak guanine nucleotide exchange factor (GEF) activity on the small GTPase Rac.^[6] TD-60 has also been shown to interact with the Chromosomal Passenger Complex (CPC), and to activate the catalytic component of the CPC, Aurora B, in the presence of microtubules.^[8][9]