RCE1

CAAX prenyl protease 2 is an enzyme that in humans is encoded by the RCE1 gene.^[5][6][7]

RCE1
Identifiers
Aliases	RCE1, FACE2, RCE1A, RCE1B, Ras converting CAAX endopeptidase 1
External IDs	OMIM: 605385; MGI: 1336895; HomoloGene: 3769; GeneCards: RCE1; OMA:RCE1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 66,842,835 bp[1] End 66,846,552 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 4,622,591 bp[2] End 4,625,641 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right hemisphere of cerebellum granulocyte right testis left testis skin of abdomen parotid gland gonad anterior pituitary skin of leg Top expressed in white adipose tissue proximal tubule right kidney bone marrow yolk sac adrenal gland placenta lip islet of Langerhans mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type endopeptidase activity endopeptidase activity metalloendopeptidase activity hydrolase activity Cellular component integral component of membrane integral component of endoplasmic reticulum membrane integral component of plasma membrane endoplasmic reticulum membrane membrane endoplasmic reticulum cytosol Biological process proteolysis CAAX-box protein processing protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9986 19671 Ensembl ENSG00000173653 ENSMUSG00000024889 UniProt Q9Y256 P57791 RefSeq (mRNA) NM_005133 NM_001032279 NM_023131 RefSeq (protein) NP_001027450 NP_005124 NP_075620 NP_001355641 NP_001355642 NP_001355643 NP_001355644 Location (UCSC) Chr 11: 66.84 – 66.85 Mb Chr 19: 4.62 – 4.63 Mb PubMed search [3] [4]
Wikidata
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This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins.^[7]