RCHY1

RING finger and CHY zinc finger domain-containing protein 1 is a protein that in humans is encoded by the RCHY1 gene.^[4]

RCHY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JRJ, 2K2C, 2K2D
Identifiers
Aliases	RCHY1, ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363, ring finger and CHY zinc finger domain containing 1
External IDs	OMIM: 607680; MGI: 1915348; HomoloGene: 22894; GeneCards: RCHY1; OMA:RCHY1 - orthologs
Gene location (Mouse) Chr. Chromosome 5 (mouse)[1] Band 5|5 E2 Start 92,096,763 bp[1] End 92,110,927 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte endothelial cell germinal epithelium islet of Langerhans right ventricle biceps brachii parietal pleura Brodmann area 23 palpebral conjunctiva Top expressed in interventricular septum zygote granulocyte secondary oocyte endocardial cushion seminal vesicula parotid gland medial ganglionic eminence molar temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding p53 binding protein binding protein homodimerization activity metal ion binding ubiquitin-protein transferase activity transferase activity signaling receptor binding Cellular component ubiquitin ligase complex cytoplasm nuclear speck nucleus nucleoplasm cytosol Biological process error-free translesion synthesis positive regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination protein autoubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25898 68098 Ensembl n/a ENSMUSG00000029397 UniProt Q96PM5 Q9CR50 RefSeq (mRNA) NM_001008925 NM_001009922 NM_001278536 NM_001278537 NM_001278538 NM_001278539 NM_015436 NM_001387136 NM_001387137 NM_001271797 NM_026557 RefSeq (protein) NP_001009922 NP_001265465 NP_001265466 NP_001265467 NP_001265468 NP_056251 NP_001258726 NP_080833 Location (UCSC) n/a Chr 5: 92.1 – 92.11 Mb PubMed search [2] [3]
Wikidata
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Function

The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.^[4]

Interactions

RCHY1 has been shown to interact with P53^[5][6] and Androgen receptor.^[7]