REEP2

Receptor expression-enhancing protein 2 is a protein that in humans is encoded by the REEP2 gene.^[5][6]

REEP2
Identifiers
Aliases	REEP2, C5orf19, SGC32445, SPG72, Yip2d, receptor accessory protein 2
External IDs	OMIM: 609347; MGI: 2385070; HomoloGene: 41146; GeneCards: REEP2; OMA:REEP2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 138,439,057 bp[1] End 138,446,969 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 34,973,642 bp[2] End 34,980,516 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe cingulate gyrus anterior cingulate cortex Brodmann area 9 nucleus accumbens prefrontal cortex amygdala anterior pituitary putamen Top expressed in zygote superior frontal gyrus dentate gyrus of hippocampal formation granule cell cerebellar cortex primary visual cortex neural layer of retina secondary oocyte supraoptic nucleus spermatid greater petrosal nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function taste receptor binding Cellular component integral component of membrane cytoplasmic microtubule integral component of plasma membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process endoplasmic reticulum tubular network organization sensory perception of bitter taste sensory perception of sweet taste protein transport into membrane raft regulation of intracellular transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51308 225362 Ensembl ENSG00000132563 ENSMUSG00000038555 UniProt Q9BRK0 Q8VCD6 RefSeq (mRNA) NM_001271803 NM_016606 NM_001204914 NM_144865 RefSeq (protein) NP_001258732 NP_057690 NP_001191843 NP_659114 Location (UCSC) Chr 5: 138.44 – 138.45 Mb Chr 18: 34.97 – 34.98 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by REEP2 belongs to a family of proteins with receptor enhancing expression capabilities, including possible enhancement of G protein-coupled receptors.^[7] The REEP2 protein shows a restricted mode of expression in human tissues.^[8]

Clinical significance

REEP2 mutations have been reported in families with hereditary spastic paraplegia.^[9]