REG3G

Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a protein that in humans is encoded by the REG3G gene.^[5][6][7][8]

REG3G
Identifiers
Aliases	REG3G, LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429, regenerating family member 3 gamma
External IDs	OMIM: 609933; MGI: 109406; HomoloGene: 128216; GeneCards: REG3G; OMA:REG3G - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 79,025,686 bp[1] End 79,028,505 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 78,443,252 bp[2] End 78,445,855 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans right testis left testis right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex pancreatic ductal cell mucosa of ileum Top expressed in crypt of lieberkuhn of small intestine respiratory epithelium nasal epithelium olfactory epithelium superior surface of tongue duodenum intestinal villus Paneth cell jejunum Ileal epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding peptidoglycan binding oligosaccharide binding transmembrane signaling receptor activity Cellular component cytoplasm extracellular region extracellular space Biological process positive regulation of wound healing positive regulation of keratinocyte proliferation negative regulation of keratinocyte differentiation inflammatory response acute-phase response MyD88-dependent toll-like receptor signaling pathway defense response to Gram-positive bacterium antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of cell population proliferation response to peptide hormone cell wall disruption in other organism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 130120 19695 Ensembl ENSG00000143954 ENSMUSG00000030017 UniProt Q6UW15 O09049 RefSeq (mRNA) NM_001008387 NM_001270040 NM_198448 NM_011260 RefSeq (protein) NP_001008388 NP_001256969 NP_940850 NP_035390 Location (UCSC) Chr 2: 79.03 – 79.03 Mb Chr 6: 78.44 – 78.45 Mb PubMed search [3] [4]
Wikidata
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Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.^[9]