REL

For other uses, see REL (disambiguation).

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene.^[5] The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer.^[6] c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.^[7]

REL
Identifiers
Aliases	REL, C-Rel, REL proto-oncogene, NF-kB subunit, HIVEN86A, IMD92
External IDs	OMIM: 164910; MGI: 97897; HomoloGene: 2182; GeneCards: REL; OMA:REL - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p16.1 Start 60,881,521 bp[1] End 60,931,612 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A3.2|11 14.36 cM Start 23,686,847 bp[2] End 23,720,970 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell bone marrow secondary oocyte bone marrow cells monocyte epithelium of colon mucosa of urinary bladder human penis cartilage tissue superficial temporal artery Top expressed in mesenteric lymph nodes blood spleen granulocyte conjunctival fornix skin of external ear bone marrow secondary oocyte cumulus cell stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding chromatin binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component cytoplasm cytosol I-kappaB/NF-kappaB complex transcription regulator complex nucleoplasm nucleus Biological process response to cytokine regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II negative regulation of interferon-beta production negative regulation of gene expression transcription, DNA-templated positive regulation of transcription, DNA-templated NIK/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response inflammatory response positive regulation of transcription by RNA polymerase II negative regulation of neuron death I-kappaB kinase/NF-kappaB signaling transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5966 19696 Ensembl ENSG00000162924 ENSMUSG00000020275 UniProt Q04864 P15307 RefSeq (mRNA) NM_001291746 NM_002908 NM_009044 RefSeq (protein) NP_001278675 NP_002899 NP_033070 Location (UCSC) Chr 2: 60.88 – 60.93 Mb Chr 11: 23.69 – 23.72 Mb PubMed search [3] [4]
Wikidata
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