RERE

For other uses, see Rere.

Arginine-glutamic acid dipeptide repeats protein is a protein that in humans is encoded by the RERE gene.^[5][6][7]

RERE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YQK
Identifiers
Aliases	RERE, ARG, ARP, ATN1L, DNB1, arginine-glutamic acid dipeptide repeats, NEDBEH
External IDs	OMIM: 605226; MGI: 2683486; HomoloGene: 8101; GeneCards: RERE; OMA:RERE - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 8,352,397 bp[1] End 8,848,921 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 81.34 cM Start 150,281,646 bp[2] End 150,621,966 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve epithelium of colon gastrocnemius muscle body of uterus muscle of thigh paraflocculus of cerebellum apex of heart canal of the cervix ganglionic eminence tibialis anterior muscle Top expressed in vestibular membrane of cochlear duct tail of embryo genital tubercle ankle joint muscle of thigh habenula neural layer of retina cerebellar cortex superior colliculus dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity sequence-specific DNA binding DNA binding transcription corepressor activity DNA-binding transcription factor activity zinc ion binding chromatin binding metal ion binding protein binding poly-glutamine tract binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component histone deacetylase complex nucleus Biological process chromatin remodeling regulation of transcription, DNA-templated dendrite morphogenesis cerebellar Purkinje cell layer maturation negative regulation of transcription by RNA polymerase II transcription, DNA-templated cerebellum development branching morphogenesis of a nerve cerebellar granule cell precursor proliferation multicellular organism development radial glia guided migration of Purkinje cell positive regulation of transcription by RNA polymerase II NLS-bearing protein import into nucleus transcription by RNA polymerase II negative regulation of nucleic acid-templated transcription regulation of transcription by RNA polymerase II positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 473 68703 Ensembl ENSG00000142599 ENSMUSG00000039852 UniProt Q9P2R6 Q80TZ9 RefSeq (mRNA) NM_001042681 NM_001042682 NM_012102 NM_001085492 RefSeq (protein) NP_001036146 NP_001036147 NP_036234 NP_001078961 Location (UCSC) Chr 1: 8.35 – 8.85 Mb Chr 4: 150.28 – 150.62 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Recent reports also indicate that RERE and its Drosophila homolog associate with histone methyltransferases in regulating gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

RERE has been shown to interact with ATN1.^[5]