REXO2

REX2, RNA exonuclease 2 homolog (S. cerevisiae), also known as REXO2, is an enzyme which in humans is encoded by the REXO2 gene.^[5][6][7]

REXO2
Identifiers
Aliases	REXO2, REX2, RFN, SFN, CGI-114, RNA exonuclease 2
External IDs	OMIM: 607149; MGI: 1888981; HomoloGene: 6447; GeneCards: REXO2; OMA:REXO2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.2 Start 114,439,435 bp[1] End 114,450,279 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 48,379,812 bp[2] End 48,391,923 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte decidua Achilles tendon stromal cell of endometrium right ventricle smooth muscle tissue vena cava saphenous vein parotid gland kidney tubule Top expressed in lacrimal gland ascending aorta hair follicle yolk sac aortic valve molar salivary gland endothelial cell of lymphatic vessel submandibular gland parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclease activity exonuclease activity hydrolase activity 3'-5' exonuclease activity nucleic acid binding 3'-5'-exoribonuclease activity Cellular component cytoplasm mitochondrial matrix mitochondrial intermembrane space nucleolus nucleus focal adhesion mitochondrion Biological process nucleobase-containing compound metabolic process nucleotide metabolic process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25996 104444 Ensembl ENSG00000076043 ENSMUSG00000032026 UniProt Q9Y3B8 Q9D8S4 RefSeq (mRNA) NM_015523 NM_024233 NM_001357501 NM_001357503 NM_001357505 RefSeq (protein) NP_056338 NP_077195 NP_001344430 NP_001344432 NP_001344434 Location (UCSC) Chr 11: 114.44 – 114.45 Mb Chr 9: 48.38 – 48.39 Mb PubMed search [3] [4]
Wikidata
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Function

Nucleases are components of DNA and RNA metabolism that carry out functions in DNA repair, replication, and recombination and in RNA processing and degradation. SFN is a homolog of Orn, a 3-prime-to-5-prime exoribonuclease of E. coli that attacks the free 3-prime hydroxyl group on single-stranded RNA, releasing 5-prime mono-nucleotides in a sequential manner.^[5]