RFWD2

E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene.^[5][6]

COP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IGQ, 5HQG
Identifiers
Aliases	COP1, RNF200, ring finger and WD repeat domain 2, E3 ubiquitin ligase, RFWD2, COP1 E3 ubiquitin ligase, FAP78, CFAP78
External IDs	OMIM: 608067; MGI: 1347046; HomoloGene: 115565; GeneCards: COP1; OMA:COP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.1-q25.2 Start 175,944,831 bp[1] End 176,207,286 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H1 Start 159,059,890 bp[2] End 159,175,210 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of transverse colon ganglionic eminence blood ventricular zone gonad white blood cell monocyte bone marrow cells skin of arm Top expressed in zygote tail of embryo genital tubercle granulocyte ventricular zone muscle of thigh spermatocyte esophagus dentate gyrus of hippocampal formation granule cell spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity zinc ion binding Cellular component nuclear speck cytosol Golgi membrane nucleus cytoplasm nucleoplasm Cul4A-RING E3 ubiquitin ligase complex centrosome focal adhesion Biological process protein ubiquitination response to ionizing radiation positive regulation of proteasomal ubiquitin-dependent protein catabolic process post-translational protein modification proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64326 26374 Ensembl ENSG00000143207 ENSMUSG00000040782 UniProt Q8NHY2 Q9R1A8 RefSeq (mRNA) NM_001001740 NM_001286644 NM_022457 NM_011931 NM_001360878 RefSeq (protein) NP_001001740 NP_001273573 NP_071902 NP_036061 NP_001347807 Location (UCSC) Chr 1: 175.94 – 176.21 Mb Chr 1: 159.06 – 159.18 Mb PubMed search [3] [4]
Wikidata
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Interactions

RFWD2 has been shown to interact with C-jun.^[7][8]