RFX2

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.^[5][6]

RFX2
Identifiers
Aliases	RFX2, regulatory factor X2
External IDs	OMIM: 142765; MGI: 106583; HomoloGene: 30980; GeneCards: RFX2; OMA:RFX2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 5,993,164 bp[1] End 6,199,572 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 D|17 29.5 cM Start 57,082,897 bp[2] End 57,138,013 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left testis right testis bronchial epithelial cell left uterine tube olfactory zone of nasal mucosa muscle layer of sigmoid colon body of uterus sural nerve left ovary Top expressed in seminiferous tubule spermatid spermatocyte zygote secondary oocyte ascending aorta choroid plexus of fourth ventricle primary oocyte blood fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity protein binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cytoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated cell differentiation spermatogenesis acrosome assembly spermatid development regulation of transcription by RNA polymerase II cell projection organization cilium assembly positive regulation of transcription by RNA polymerase II cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5990 19725 Ensembl ENSG00000087903 ENSMUSG00000024206 UniProt P48378 P48379 RefSeq (mRNA) NM_000635 NM_134433 NM_009056 NM_027787 RefSeq (protein) NP_000626 NP_602309 NP_033082 NP_082063 Location (UCSC) Chr 19: 5.99 – 6.2 Mb Chr 17: 57.08 – 57.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.^[6]