RGS1

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.^[5][6][7]

RGS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BV1, 2GTP
Identifiers
Aliases	RGS1, 1R20, BL34, HEL-S-87, IER1, IR20, regulator of G-protein signaling 1, regulator of G protein signaling 1
External IDs	OMIM: 600323; MGI: 1354694; HomoloGene: 2191; GeneCards: RGS1; OMA:RGS1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.2 Start 192,575,763 bp[1] End 192,580,024 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 F|1 62.56 cM Start 144,118,034 bp[2] End 144,124,980 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment olfactory bulb right lung rectum appendix tibial nerve gallbladder lymph node epithelium of nasopharynx right uterine tube Top expressed in stroma of bone marrow mesenteric lymph nodes granulocyte spleen duodenum large intestine colon jejunum pyloric antrum decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein alpha-subunit binding GTPase activator activity calmodulin binding GTPase activity Cellular component extrinsic component of cytoplasmic side of plasma membrane cytosol plasma membrane membrane cytoplasm Biological process G protein-coupled receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction leukotriene signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway immune response regulation of G protein-coupled receptor signaling pathway signal transduction response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5996 50778 Ensembl ENSG00000090104 ENSMUSG00000026358 UniProt Q08116 Q9JL25 RefSeq (mRNA) NM_002922 NM_015811 RefSeq (protein) NP_002913 NP_056626 Location (UCSC) Chr 1: 192.58 – 192.58 Mb Chr 1: 144.12 – 144.12 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.^[7]