RGS13

Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.^[5][6]

RGS13
Identifiers
Aliases	RGS13, regulator of G protein signaling 13
External IDs	OMIM: 607190; MGI: 2180585; HomoloGene: 14774; GeneCards: RGS13; OMA:RGS13 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.2 Start 192,636,138 bp[1] End 192,660,311 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 F|1 62.56 cM Start 144,014,392 bp[2] End 144,053,110 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix jejunal mucosa lymph node gallbladder mucosa of sigmoid colon tonsil pancreatic epithelial cell mucosa of transverse colon duodenum rectum Top expressed in cumulus cell Paneth cell morula mesenteric lymph nodes jejunum epithelium of stomach duodenum medulla of thymus olfactory epithelium dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity GTPase activity Cellular component cytoplasm cytosol nucleus plasma membrane Biological process G protein-coupled receptor signaling pathway negative regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6003 246709 Ensembl ENSG00000127074 ENSMUSG00000051079 UniProt O14921 Q8K443 RefSeq (mRNA) NM_144766 NM_002927 NM_153171 RefSeq (protein) NP_002918 NP_658912 NP_694811 Location (UCSC) Chr 1: 192.64 – 192.66 Mb Chr 1: 144.01 – 144.05 Mb PubMed search [3] [4]
Wikidata
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RGS13 is a member of R4 subfamily of the Regulator of G protein signaling (RGS) protein family, whose members have only short peptide sequences flanking the RGS domain. RGS13 suppresses the immunoglobulin E- mediated allergic responses.^[7]

RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.^[6]