RGS16

Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene.^[5][6]

RGS16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BT2, 2IK8
Identifiers
Aliases	RGS16, A28-RGS14, A28-RGS14P, RGS-R, regulator of G-protein signaling 16, regulator of G protein signaling 16
External IDs	OMIM: 602514; MGI: 108407; HomoloGene: 2196; GeneCards: RGS16; OMA:RGS16 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 182,598,623 bp[1] End 182,604,389 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G3|1 65.43 cM Start 153,616,095 bp[2] End 153,621,214 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus vena cava oocyte tendon of biceps brachii cartilage tissue left lobe of thyroid gland right lobe of thyroid gland anterior pituitary saphenous vein gastric mucosa Top expressed in medial geniculate nucleus suprachiasmatic nucleus medial dorsal nucleus lateral geniculate nucleus internal carotid artery external carotid artery Rostral migratory stream islet of Langerhans neural layer of retina perirhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity calmodulin binding GTPase activity Cellular component cytoplasm plasma membrane membrane intrinsic component of membrane Biological process negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway visual perception positive regulation of GTPase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6004 19734 Ensembl ENSG00000143333 ENSMUSG00000026475 UniProt O15492 P97428 RefSeq (mRNA) NM_002928 NM_011267 RefSeq (protein) NP_002919 NP_035397 Location (UCSC) Chr 1: 182.6 – 182.6 Mb Chr 1: 153.62 – 153.62 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade.^[6]

Interactions

RGS16 has been shown to interact with GNAQ^[7] and GNAI3.^[8][9]