RGS3

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.^[5][6][7]

RGS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F5Y, 2OJ4, 3FBK
Identifiers
Aliases	RGS3, C2PA, RGP3, regulator of G-protein signaling 3, regulator of G protein signaling 3
External IDs	OMIM: 602189; MGI: 1354734; HomoloGene: 32440; GeneCards: RGS3; OMA:RGS3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q32 Start 113,444,731 bp[1] End 113,597,743 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B3|4 33.19 cM Start 62,478,084 bp[2] End 62,622,238 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart cartilage tissue periodontal fiber ascending aorta Descending thoracic aorta left ventricle gallbladder right auricle of heart lateral nuclear group of thalamus granulocyte Top expressed in zygote granulocyte ventricular zone genital tubercle secondary oocyte external carotid artery internal carotid artery spermatid yolk sac neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity GTPase activity Cellular component plasma membrane membrane nucleus nucleoplasm cytosol cytoplasm Biological process negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5998 50780 Ensembl ENSG00000138835 ENSMUSG00000059810 UniProt P49796 Q9DC04 RefSeq (mRNA) NM_001276260 NM_001276261 NM_001276262 NM_001282922 NM_001282923 NM_017790 NM_130795 NM_134427 NM_144488 NM_144489 NM_001322214 NM_001322215 NM_001351526 NM_001394167 NM_001081650 NM_019492 NM_134257 NM_001310706 RefSeq (protein) NP_001263189 NP_001263190 NP_001263191 NP_001269851 NP_001269852 NP_001309143 NP_001309144 NP_060260 NP_570613 NP_602299 NP_652759 NP_652760 NP_001338455 NP_001263189.1 NP_001269851.1 NP_001075119 NP_001297635 NP_062365 NP_599018 Location (UCSC) Chr 9: 113.44 – 113.6 Mb Chr 4: 62.48 – 62.62 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.^[7]