RGS5

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.^[5][6]

RGS5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRP
Identifiers
Aliases	RGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, regulator of G-protein signaling 5, regulator of G protein signaling 5
External IDs	OMIM: 603276; MGI: 1098434; HomoloGene: 2682; GeneCards: RGS5; OMA:RGS5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 163,111,121 bp[1] End 163,321,791 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.3|1 76.84 cM Start 169,483,070 bp[2] End 169,523,382 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta cardia urethra pylorus popliteal artery tibial arteries ascending aorta visceral pleura seminal vesicula right ventricle Top expressed in tunica media of zone of aorta transitional epithelium of urinary bladder body of femur ankle olfactory epithelium digastric muscle sternocleidomastoid muscle temporal muscle triceps brachii muscle medial head of gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity GTPase activity Cellular component plasma membrane membrane cytoplasm cytosol Biological process negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8490 19737 Ensembl ENSG00000143248 ENSMUSG00000026678 UniProt O15539 O08850 RefSeq (mRNA) NM_001195303 NM_001254748 NM_001254749 NM_003617 NM_025226 NM_009063 NM_001313705 RefSeq (protein) NP_001182232 NP_001241677 NP_001241678 NP_003608 NP_003608.1 NP_001300634 NP_033089 Location (UCSC) Chr 1: 163.11 – 163.32 Mb Chr 1: 169.48 – 169.52 Mb PubMed search [3] [4]
Wikidata
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The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.^[6]

Interactions

RGS5 has been shown to interact with GNAO1,^[7][8] GNAI2^[7][8] and GNAI3.^[7][8]