RGS8

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.^[5][6]

RGS8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IHD, 2ODE, 5DO9
Identifiers
Aliases	RGS8, regulator of G protein signaling 8
External IDs	OMIM: 607189; MGI: 108408; HomoloGene: 23152; GeneCards: RGS8; OMA:RGS8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 182,641,816 bp[1] End 182,684,587 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G3|1 65.41 cM Start 153,528,771 bp[2] End 153,576,069 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus nucleus accumbens Pons putamen caudate nucleus cerebellar vermis testicle gonad sperm pars reticulata Top expressed in lobe of cerebellum cerebellar vermis neural layer of retina medial geniculate nucleus medial dorsal nucleus superior colliculus lateral geniculate nucleus olfactory tubercle inferior colliculi dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding GTPase activator activity GTPase activity Cellular component cytoplasm extrinsic component of cytoplasmic side of plasma membrane neuronal cell body membrane perikaryon plasma membrane dendrite cell projection membrane nucleus Biological process G protein-coupled acetylcholine receptor signaling pathway regulation of dopamine receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85397 67792 Ensembl ENSG00000135824 ENSMUSG00000042671 UniProt P57771 Q8BXT1 RefSeq (mRNA) NM_001102450 NM_033345 NM_001369564 NM_001387847 NM_001387848 NM_001387849 NM_026380 NM_001347115 NM_001357525 RefSeq (protein) NP_001095920 NP_203131 NP_001356493 NP_001334044 NP_080656 NP_001344454 Location (UCSC) Chr 1: 182.64 – 182.68 Mb Chr 1: 153.53 – 153.58 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.^[6]